If you find a 'Superior' piece of armor with +Enhanced Defense, a Superior Weapon with +Enhanced Damage or a Helm/Weapon that has +Skill bonuses for a certain class, all of these will remain on the final Rune Word that is created. Keep in mind that all Rune Words you create will retain any pre-existing bonuses found on the item. Sorceress' come with Teleport built into their class and Amazons have too slow of frames when casting to make Teleport as useful for them.
Some of the builds for these classes are based entirely around Enigma and won't function without it. Necromancers, Paladins, Druids, basically every character except Sorceress' and Amazons will have a build or two that Enigma is the recommended best in slot item for. Enigma is the most popular best in slot Rune Word in the entire game because it is one of the only items that offers the Teleport ability.
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